sonia trigueros

Ph.D. (2002). Molecular Genetics. The University of Barcelona. Spain

Master in Biotechnology (1995-1997). The University of Barcelona. Spain.

Bachelor in Biology (1995). The University of Barcelona. Spain.

Research Experience

Associated Researcher (NOv 2017-‐ Current Position) Department of Zoology. The University of Oxford. South Parks Road.OX13PS UK.

Academic Fellow (Sept 2012-‐ Current Position) Oxford Martin Institute of Nanoscience for Medicine and Department of Physics. The University of Oxford. Parks Road.OX13PU UK.

Senior Research Fellow (April 2010-‐Sept 2012) Oxford Martin Institute of Nanoscience for Medicine and Department of Physics. University of Oxford. Parks Road.OX13PU UK

Research Fellow (2009-‐2010). Oxford Martin Institute of Nanoscience for Medicine and Department of Physics. University of Oxford. Parks Road.OX13PU UK

Visiting Professor (2009-‐current status) CNIC/ University of Havana. Havana. Cuba

Senior Research Postdoc (2007-‐2008) Bionanotechnology IRC.Department of Physics. University of Oxford. Parks Road.OX13PU UK

Postdoctoral Research (2004-‐2007) Laboratory of Professor David Sherratt Department of Biochemistry. Microbiology Unit. University of Oxford.

Postdoctoral Research (2001-‐2004). Molecular Biology ResearchLaboratory of Professor James C. Wang. Department of Molecular and Cellular Biology MCB. Harvard University.7-‐ Divinity Avenue, Cambridge MA, 02138, USA.

Visiting Researcher (June 2006) Laboratory of Professor Nicholas R. Cozzarelli Department of Molecular and Cell Biology University of California, Berkeley, CA

Visiting Researcher (July-‐September 2005) Laboratory of Professor Kiyoshi MizuuchiLMB/NIDDK/NIH. Bethesda, MD 20892, USA

Selected Publications and Patents

Nano-scale gene delivery systems: current technology, obstacles, and future directions

A Garcia-Guerra, TL Dunwell, S Trigueros

Current medicinal chemistry 25 (21), 2448-2464. 2018

Nano-Gene-Delivery: Overcoming One of the Major Challenges in Gene Therapy.

Sonia Trigueros

Research in Medical and Engineering Sciences

July 2018. DOI: 10.31031/RMES.2018.06.000633

Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System . Nurul A C Lah, Mahendran Samykano1 and Sonia Trigueros. Journal of NanoMedicine Research. Volume 4 issue 2 (2016)

PATENT 2015
Sorting pristine nanoparticles/nanostructures by reversible attachment of circular double-‐stranded DNA. IP Sonia Trigueros Dec 2015

Characterization of the RstB2 protein, the DNA binding protein of CTXΦ phage from Vibrio cholerae",Alina Falero, Sonia Trigueros and Rafael Fando. Virus Genes 03/2014; (2014)

SpoIIIE mechanism of directional translocation involves target search coupled to sequence-‐dependent motor stimulation.Diego I Cattoni, Osvaldo Chara, Cédric Godefroy, Emmanuel Margeat, Sonia Trigueros, Pierre-‐Emmanuel Milhiet, Marcelo Nöllmann
EMBO Reports 2013

Three strategies to stabilise nearly monodispersed silver nanoparticles in aqueous solution. (AP Stevenson, D Blanco Bea, S Civit, S Antoranz Contera, A Iglesias Cerveto, S Trigueros. Nanoscale Res Lett 7 (2012) (151-‐ 160)

Mapping nanomechanical properties of live cells using multi-‐harmonic atomic force microscopy. Raman1,3†*, S. Trigueros2†, A. Cartagena1,3, A. P. Z. Stevenson2, M. Susilo1, E. Nauman1,4 and S. Antoranz Contera2
These authors contributed equally to this work: A. Raman & S. Trigueros
Nature Nanotechnology (2011)

Characterization of pVVGJΦ, the single-‐stranded DNA binding protein of the phage VGJΦ of Vibrio cholerae. Alina Falero*, Andy Caballero, Sonia Trigueros, M. Cuevas and Rafael Fando.
Biochimica et biophysica acta. 09/2011; 1814(9):1107-‐12.( 2011)

Mwr Xer site-‐specific recombination is hypersensitive to DNA supercoiling.
Sonia Trigueros, Tung Tran, Nohemy Sorto, Jason Newmark, Sean D. Colloms, David J. Sherratt and Marcelo E. Tolmasky Nucleic Acids Research, 2009, Vol. 37, No. 11 3580-‐3587
Received October 29, 2008. Revised February 24, 2009. Accepted March 11, 2009.
Corresponding Author.

Role of replicative transposons in plasmids' host range expansion: Implications in dissemination of antibiotic resistance. DB Buii, N Sorto, S Trigueros, JS Newmark, DJ Sherratt, ME Tolmasky
PLASMID. vol 57 (2007) 231-‐234

Production of highly knotted DNA by means of cosmid circularization inside phage capsids. Sonia Trigueros and Joaquim Roca.Institut de Biologia Molecular de Barcelona, CSIC, Jordi Girona 18-‐26, 08034 Barcelona, Spain. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK BMC Biotechnology 2007.

Differences inresolution of mrw-‐containing plasmid dimmers mediated by Klebsiella pneumoniae and Escherichia coli XerC recombinases.Duyen Bui, Judianne Ramiscal, Sonia Trigueros, Jason Newmark, Albert Do, David Sherratt and Marcelo Tolmasky.J. Bacteriol.188, 2812-‐2820 (2006).

Javier Arsuaga, Mariel Vazquez, Paul Mc Guirk, Sonia Trigueros, De Witt Sumners, and Joaquim Roca. DNA knots reveal a chiral organization of DNA in phage capsids.
Proc. Natl. Acad. Sci. 102, No 26, 9165-‐9169 (2005)

Sonia Trigueros, Javier Salceda, Ignacio Bermudez, Xavier Fernandez and Joaquim Roca. Asymmetric removal of supercoils suggests how topoisomerase II simplifies DNA topology. J. Mol. Biol. Jan 16; 335 (3):723-‐31 (2004).

Tobias Hanke, Maria J.Ramiro, Sonia Trigueros, Joaquim Roca and Vicente Larraga.
Cloning, functional analysis and post-‐transcriptional regulation of a type II DNA Topoisomerase from Leishmaniainfantum. A new potential target for anti parasite drugs.
Nucleic. Acids. Res. 31, No16, 4917-‐4928 (2003).

Sonia Trigueros and Joaquim Roca
A GyrB-‐GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II.
Genes to Cells Vol. 7, Issue 3, 249-‐257 (2002).

Failure to relax negative supercoiling of DNA is a primary cause of mitotic Hyper-‐recombination in topoisomerase-‐deficient yeast cells. Sonia Trigueros and Joaquim Roca J. Biol. Chem. 277, 37207-‐37211 (2002).

Knotting probability of DNA molecules confined in restricted volumes: DNA knotting in Phage capsids. Javier Arsuaga, Mariel Vazquez, Sonia Trigueros, De Witt Sumners, and Joaquim Roca Proc. Natl. Acad. Sci. USA 99, 5373-‐5377 (2002).

Circular minichromosomes become highly recombinogenic in topoisomerase-‐deficient yeast cells. Sonia Trigueros and Joaquim RocaJ. Biol. Chem. 276, 2243-‐2249 (2001).

Novel display of knotted DNA molecules by two-‐dimensional gel electrophoresis. Sonia Trigueros, Javier Arsuaga, Maria E. Vazquez, De Witt Sumners and Joaquim RocaNucleic. Acids. Res.29,No13 -‐ (2001).